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Moving forward, collaborative efforts among researchers, healthcare professionals, and policymakers are essential to advance nephroprotection using traditional medicinal plants

To this end, we constructed a LiCl-exposed pregnant mouse model by orally giving 0, 3.6, 20, 100, or 200 mg/kg/d LiCl (corresponding to 0, 1, 5.6, 28, and 56 -fold REED of Li) for continuous 13 days (Fig

Sadhu SS, Wang S, Dachineni R, Averineni RK, Seefeldt T, Xie J, et al

Clinical safety is paramount

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In the model cytosolic GSH has three fates: it is transported into the blood, there is a net flux to GSSG, and 0.2% is removed per hour corresponding to detoxification reactions and excretion into the bile